...are your prospective employers the art chosing department of the NHS?
Story here
I've just made a similar decision. Stay with a very comfortable job on reasonable money or make the break and go self-employed - although I've yet to pay myself a wage let alone a £38k bonus
I chose the tough option primarily 'cos I can see that in the next couple of years my circumstances wouldn't suit being 'unwaged' and pressurised. Additionally I have an idea of a lifestyle which I want to achieve - this would be impossible in any job I was qualified to apply for (25 days holiday, etc...).
It's hard work and I'm aware that I may or may not be successful, however I'm also aware that I can, and have plenty of time to, bounce back should the need arise.
Yours won't be an easy decision, unless you are completely money motivated, so think long and hard - speak to their current employees (re: turnover of staff, probation periods especially).
....and most of all good luck whatever you choose.
Steve